Generation of spiral waves on the boundary.


Cell layer was loaded with Fluo-4 and observed using confocal setup. Propagation to the inner zone is impeded by the continuous presence of the cell uncoupler heptanol, border cell automaticity is increased due to isoproterenol. Note: the acquisition window was moved during the experiment alongside the boundary to center the events. Details in Biktashev et al, Biophysical J 2008 [PDF]



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